MECOM-AS1

Across TCGA pan-cancer cohorts, MECOM-AS1 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated MECOM-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher MECOM-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MECOM-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRP, UVM, and KIRC are the cancer types where MECOM-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.571	0.736	<.001	98	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	45	view →
KIRC	DFS	Quartile	All	0.802	0.478	<.001	36	view →
UCS	OS	Tertile	IV	0.781	0.206	.024	34	view →
PAAD	DFS	Tertile	All	0.197	0.462	.003	31	view →
LUAD	OS	Quartile	All	0.654	0.308	.008	25	view →
LUSC	DFS	Median	All	0.823	0.593	.001	25	view →
BLCA	DFS	Median	IV	0.572	0.372	.005	18	view →
HNSC	OS	Tertile	IV	0.842	0.458	.004	15	view →
CESC	OS	Quartile	All	0.889	0.717	.004	8	view →
STAD	OS	Median	IV	0.318	0.709	.011	6	view →
LIHC	DFS	Median	II,III,IV	0.314	0.169	.033	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

MECOM-AS1–KIRP (OS)

Open the KIRP breakdown →