MEAF6

Across TCGA patient cohorts, MEAF6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MEAF6-associated genes across cancer lineages are Shc_pY317, Caspase-7-cleavedD198, and eEF2. Each is linked with MEAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MEAF6-to-partner and partner-to-MEAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by MEAF6-low versus MEAF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MEAF6→partner) and Y-score (partner→MEAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.280	-3.459	<.001	.005	3	2
UCEC	Caspase-7-cleavedD198 →	+0.693	+2.189	.012	.034	3	2
UCEC	eEF2 →	+0.411	+2.584	.013	.011	3	1
UCEC	EGFR_pY1068 →	-0.348	-3.459	.002	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.251	-3.459	.001	.005	3	1
UCEC	Ku80 →	+0.279	+2.598	.011	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Shc_pY317 by MEAF6 expression — UCEC

Explore this box plot interactively →