ME2

Across TCGA cell cohorts, ME2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,587 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ME2-associated GO terms across cancer lineages are Left ventricular cardiac muscle tissue morphogenesis, Negative regulation of cell cycle checkpoint, and Establishment of meiotic spindle orientation. Each is linked with ME2 in more than 11 cancer types. Because this analysis shows association rather than direction, both ME2-to-partner and partner-to-ME2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Left ventricular cardiac muscle tissue morphogenesis grouped by ME2-low versus ME2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ME2→partner) and Y-score (partner→ME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Left ventricular cardiac muscle tissue morphogenesis →	+0.967	+1.594	.004	.001	3	11
OVARY	Negative regulation of cell cycle checkpoint →	+0.181	+1.324	<.001	<.001	3	11
STOMACH	Establishment of meiotic spindle orientation →	+0.183	+1.018	.001	.002	2	12
LARGE_INTESTINE	Purine deoxyribonucleoside monophosphate biosynthetic process →	+0.113	+1.135	<.001	<.001	3	10
LARGE_INTESTINE	DAMP biosynthetic process →	+0.113	+1.135	<.001	<.001	3	10
BREAST	Negative regulation of mitotic spindle assembly checkpoint signaling →	+0.160	+1.301	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,587 associations by consensus.

Left ventricular cardiac muscle tissue morphogenesis by ME2 expression — PANCREAS

Explore this box plot interactively →