Across TCGA patient cohorts, MDS2 mutation is significantly associated with the RNA expression of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDS2-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RNA5SP419. Each is linked with MDS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDS2-to-partner and partner-to-MDS2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDS2→partner) and Y-score (partner→MDS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+1.195	+3.670	<.001	.002	3	2
UCEC	RNA5SP411 →	+2.054	+3.715	<.001	.001	3	2
UCEC	RNA5SP419 →	+1.326	+3.492	<.001	.003	3	2
UCEC	RNA5SP410 →	+1.174	+3.204	<.001	.006	3	2
UCEC	RNA5SP416 →	+1.359	+3.639	<.001	.002	3	2
UCEC	RNA5SP421 →	+1.487	+3.018	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

Exploration

MDS2 survival (RNA) · tumor vs normal (RNA) · all MDS2 data types