Across TCGA cell cohorts, MDS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,236 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDS2-associated GO terms across cancer lineages are Negative regulation of fatty acid transport, Negative regulation of peptidase activity, and Negative regulation of T-helper 17 cell lineage commitment. Each is linked with MDS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MDS2-to-partner and partner-to-MDS2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDS2→partner) and Y-score (partner→MDS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of fatty acid transport →	-0.146	-0.136	<.001	<.001	3	4
BLOOD_Lymphoma	Negative regulation of peptidase activity →	-0.730	-0.650	.001	.009	3	4
BLOOD_Leukemia	Negative regulation of T-helper 17 cell lineage commitment →	-0.164	-0.144	<.001	.002	3	4
SOFT_TISSUE	Positive regulation of ferroptosis →	-0.104	-0.262	.001	.003	3	3
SOFT_TISSUE	Megakaryocyte development →	-0.081	-0.246	.003	.002	3	3
SOFT_TISSUE	Polysaccharide digestion →	+0.124	+0.245	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,236 associations by consensus.

Exploration

MDS2 survival (RNA) · tumor vs normal (RNA) · all MDS2 data types