MDN1

Across TCGA pan-cancer cohorts, MDN1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MDN1 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher MDN1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MDN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CESC show a favorable association.

THYM, UCEC, and COAD are the cancer types where MDN1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.825	0.422	.012	16	view →
COAD	OS	Median	IV	0.056	0.659	<.001	9	view →
SARC	OS	Median	All	0.171	0.734	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
KIRC	OS	Median	All	0.243	0.630	.048	2	view →
CESC	OS	Median	All	0.905	0.557	.049	2	view →
SKCM	DFS	Median	III,IV	0.528	0.192	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MDN1–THYM (OS)

Open the THYM breakdown →