MDN1

Across TCGA pan-cancer cohorts, MDN1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MDN1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MDN1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MDN1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and COAD show a favorable association.

LSCC, COAD, and CCRCC are the cancer types where MDN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.873	0.435	.006	19	view →
COAD	DFS	Median	II,III,IV	1.000	0.897	.042	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.147	0.928	.020	12	view →
GBM	OS	Quartile	All	0.662	0.273	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MDN1–LSCC (DFS)

Open the LSCC breakdown →