MDN1

Across TCGA patient cohorts, MDN1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,969 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDN1-associated genes across cancer lineages are GINS4, PM20D2, and MSH2. Each is linked with MDN1 in more than 7 cancer types. Because this analysis shows association rather than direction, both MDN1-to-partner and partner-to-MDN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDN1 versus GINS4 in LSCC, with a Pearson correlation of 0.48.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDN1→partner) and Y-score (partner→MDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GINS4 →	+0.763	+0.247	<.001	<.001	3	8
BRCA	PM20D2 →	+1.369	+0.464	<.001	<.001	3	8
LSCC	MSH2 →	+0.648	+0.275	<.001	<.001	3	7
LSCC	HDAC2 →	+0.642	+0.323	<.001	<.001	3	7
HNSC	VRK1 →	+0.719	+0.208	<.001	<.001	3	7
LUAD	GINS1 →	+0.850	+0.225	.002	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,969 associations by consensus.

MDN1 vs GINS4 — LSCC

Explore this scatter interactively →