MDN1

Across TCGA patient cohorts, MDN1 mutation is significantly associated with the RNA expression of many other genes, with 10,198 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDN1-associated genes across cancer lineages are BCCIP, WARS1, and CISD2. Each is linked with MDN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MDN1-to-partner and partner-to-MDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCCIP grouped by MDN1-low versus MDN1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDN1→partner) and Y-score (partner→MDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	BCCIP →	+0.432	+2.596	<.001	<.001	3	6
UCEC	WARS1 →	+0.519	+1.458	<.001	<.001	3	6
COAD	CISD2 →	+0.323	+2.123	<.001	<.001	3	6
UCEC	H2AZ1 →	+0.537	+1.550	<.001	<.001	3	6
CESC	FCER1A →	-1.028	-3.321	.003	.008	3	6
STAD	PHF5A →	+0.458	+2.449	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,198 associations by consensus.

BCCIP by MDN1 expression — LUAD

Explore this box plot interactively →