MDN1

Across TCGA cell cohorts, MDN1 mutation is significantly associated with the RNA expression of many other genes, with 2,889 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDN1-associated genes across cancer lineages are GNPNAT1, C1QBP, and HIP1. Each is linked with MDN1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MDN1-to-partner and partner-to-MDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNPNAT1 grouped by MDN1-low versus MDN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDN1→partner) and Y-score (partner→MDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GNPNAT1 →	+0.675	+2.588	<.001	<.001	3	4
LARGE_INTESTINE	C1QBP →	+0.872	+3.067	<.001	<.001	3	4
LARGE_INTESTINE	HIP1 →	+0.873	+1.569	<.001	.001	3	4
LARGE_INTESTINE	LTV1 →	+0.519	+3.541	<.001	<.001	3	4
LARGE_INTESTINE	PRPSAP2 →	+0.599	+2.113	<.001	<.001	3	4
LARGE_INTESTINE	FEM1A →	+0.683	+2.113	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,889 associations by consensus.

GNPNAT1 by MDN1 expression — LARGE_INTESTINE

Explore this box plot interactively →