MDN1

Across TCGA cell cohorts, MDN1 mutation is significantly associated with the mutation status of many other genes, with 4,760 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDN1-associated genes across cancer lineages are PCSK5, PKHD1, and KMT2A. Each is linked with MDN1 in more than 9 cancer types. Because this analysis shows association rather than direction, both MDN1-to-partner and partner-to-MDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCSK5 grouped by MDN1-low versus MDN1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDN1→partner) and Y-score (partner→MDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PCSK5 →	+2.822	+2.032	<.001	<.001	1	10
STOMACH	PKHD1 →	+2.459	+1.999	.006	.006	1	7
STOMACH	KMT2A →	+3.781	+2.215	.003	.003	1	6
LARGE_INTESTINE	KMT2D →	+2.175	+2.604	<.001	<.001	1	6
SKIN	PCDH9 →	+2.860	+2.018	.002	.002	1	6
UPPER_AERODIGESTIVE_TRACT	PLXNA3 →	+4.442	+3.217	.004	.004	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,760 associations by consensus.

PCSK5 by MDN1 expression — LARGE_INTESTINE

Explore this box plot interactively →