Across TCGA pan-cancer cohorts, MDM4 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MDM4 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MDM4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDM4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, LUAD, and COAD are the cancer types where MDM4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.122	0.685	.001	33	view →
LUAD	OS	Median	All	0.090	0.788	<.001	18	view →
COAD	OS	Median	All	0.001	0.871	<.001	12	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
UCEC	DFS	Median	All	1.000	0.624	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: MDM4 tumor-vs-normal RNA expression · all MDM4 data types