MDM2

Across TCGA pan-cancer cohorts, MDM2 mass-spec protein differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of MDM2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MDM2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MDM2 is over-expressed in tumor.

LUAD and LSCC are the cancer types where MDM2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MDM2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.422	.002	2	view →
LSCC	All	All	+0.369	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

MDM2–LUAD

Open the LUAD breakdown →