MDM2

Across TCGA patient cohorts, MDM2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,309 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MDM2-associated genes across cancer lineages are CRB2, IFITM5, and RNU7-55P. Each is linked with MDM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM2-to-partner and partner-to-MDM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDM2 versus CRB2 in GBM, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM2→partner) and Y-score (partner→MDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CRB2 →	-1.548	-0.617	<.001	<.001	3	2
UCEC	IFITM5 →	-1.487	-0.415	.007	<.001	3	2
CCRCC	RNU7-55P →	-1.266	-0.654	<.001	.001	3	2
UCEC	NCEH1 →	-1.117	-0.407	.003	.006	3	2
UCEC	RNU6-530P →	-1.892	-0.442	.003	<.001	3	2
BRCA	SLC5A4 →	+0.573	+0.501	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,309 associations by consensus.

MDM2 vs CRB2 — GBM

Explore this scatter interactively →