MDM2

Across TCGA patient cohorts, MDM2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDM2-associated genes across cancer lineages are Rad50, JNK_pT183_Y185, and Notch1. Each is linked with MDM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM2-to-partner and partner-to-MDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MDM2-low versus MDM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM2→partner) and Y-score (partner→MDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.202	-1.906	.039	.016	3	2
UCEC	JNK_pT183_Y185 →	-0.146	-1.893	.031	.016	3	1
UCEC	Notch1 →	+0.173	+2.594	.002	.006	3	1
UCEC	SCD →	+0.098	+1.920	.026	.009	3	1
UCEC	TAZ →	-0.139	-1.906	.014	.016	3	1
UCEC	ATM →	-0.491	-3.321	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Rad50 by MDM2 expression — UCEC

Explore this box plot interactively →