MDM2

Across TCGA cell cohorts, MDM2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDM2-associated genes across cancer lineages are DEFA3, FAM71A, and IL20. Each is linked with MDM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM2-to-partner and partner-to-MDM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by MDM2-low versus MDM2-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM2→partner) and Y-score (partner→MDM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DEFA3 →	+0.090	+5.169	<.001	.004	3	1
LARGE_INTESTINE	FAM71A →	+0.058	+2.716	<.001	.009	3	1
LARGE_INTESTINE	IL20 →	+0.177	+2.984	<.001	.005	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

DEFA3 by MDM2 expression — BONE

Explore this box plot interactively →