MDM1

Across TCGA pan-cancer cohorts, MDM1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MDM1 data layer compared with 28 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher MDM1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDM1 expression acts as an unfavorable survival marker.

ESCA, SARC, and LUSC are the cancer types where MDM1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Median	All	0.124	0.536	.001	12	view →
SARC	DFS	Median	All	0.024	0.611	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.139	0.663	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MDM1–ESCA (DFS)

Open the ESCA breakdown →