MDM1

Across TCGA patient cohorts, MDM1 protein abundance is significantly associated with the RNA expression of many other genes, with 9,187 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDM1-associated genes across cancer lineages are CBX7, SPEF1, and CENPA. Each is linked with MDM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MDM1-to-partner and partner-to-MDM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDM1 versus CBX7 in BRCA, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM1→partner) and Y-score (partner→MDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CBX7 →	+0.620	+0.344	.005	.001	3	4
UCEC	SPEF1 →	+1.560	+0.439	<.001	<.001	3	4
BRCA	CENPA →	-0.958	-0.417	.005	.004	3	4
UCEC	CCDC170 →	+1.110	+0.593	<.001	<.001	3	4
GBM	ATP8A1 →	+0.818	+0.264	<.001	.001	3	4
LUAD	BPIFB1 →	+2.128	+0.310	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,187 associations by consensus.

MDM1 vs CBX7 — BRCA

Explore this scatter interactively →