MDM1

Across TCGA patient cohorts, MDM1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDM1-associated genes across cancer lineages are GAPDH, p70-S6K, and ATM. Each is linked with MDM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM1-to-partner and partner-to-MDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MDM1-low versus MDM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM1→partner) and Y-score (partner→MDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.429	+2.999	.037	.035	3	2
UCEC	p70-S6K →	+0.186	+3.604	.011	.001	3	2
UCEC	ATM →	-0.467	-2.321	.007	.034	3	2
UCEC	cIAP →	+0.126	+1.594	.016	.042	3	2
UCEC	4E-BP1 →	+0.359	+2.087	<.001	.005	3	2
UCEC	Cyclin-B1 →	+0.630	+1.678	.003	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

GAPDH by MDM1 expression — UCEC

Explore this box plot interactively →