MDM1

Across TCGA cell cohorts, MDM1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible MDM1-associated genes across cancer lineages are OR14A16, TARM1, and DEFA6. Each is linked with MDM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDM1-to-partner and partner-to-MDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A16 grouped by MDM1-low versus MDM1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDM1→partner) and Y-score (partner→MDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR14A16 →	+0.032	+5.321	<.001	.005	3	2
CNS	TARM1 →	+0.029	+5.321	<.001	.005	3	1
OVARY	DEFA6 →	+0.231	+5.196	<.001	.005	3	1
OVARY	TSPY10 →	+0.035	+5.196	<.001	.005	3	1
STOMACH	IL5 →	+0.123	+3.688	<.001	.007	3	1
STOMACH	TMSB4Y →	+1.001	+3.906	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OR14A16 by MDM1 expression — CNS

Explore this box plot interactively →