MDK

Across TCGA pan-cancer cohorts, MDK mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MDK data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MDK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDK expression acts as an unfavorable survival marker.

COAD, CCRCC, and PDAC are the cancer types where MDK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.905	1.000	.007	114	view →
CCRCC	OS	Quartile	All	0.492	0.915	.001	75	view →
PDAC	OS	Median	All	0.669	0.971	.001	55	view →
GBM	DFS	Tertile	All	0.265	0.491	.013	12	view →
HNSC	OS	Median	All	0.956	1.000	.014	7	view →
LUAD	DFS	Tertile	All	0.521	0.813	.012	4	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MDK–COAD (DFS)

Open the COAD breakdown →