MDK

Across TCGA pan-cancer cohorts, MDK mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of MDK’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MDK mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MDK is over-expressed in tumor.

COAD, PDAC, and LUAD are the cancer types where MDK tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MDK mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+0.607	<.001	11	view →
PDAC	Female	II,III,IV	+1.701	<.001	10	view →
LUAD	Female	III,IV	+1.385	<.001	9	view →
LSCC	Male	All	+1.006	<.001	7	view →
CCRCC	Female	IV	+2.260	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

MDK–COAD

Open the COAD breakdown →