MDK

Across TCGA cell cohorts, MDK mutation is significantly associated with the mutation status of many other genes, with 691 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDK-associated genes across cancer lineages are DNAJC1, ILF2, and BDH1. Each is linked with MDK in more than 1 cancer types. Because this analysis shows association rather than direction, both MDK-to-partner and partner-to-MDK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNAJC1 grouped by MDK-low versus MDK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDK→partner) and Y-score (partner→MDK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DNAJC1 →	+4.894	+4.894	.004	.004	1	2
BLOOD_Leukemia	ILF2 →	+5.894	+5.321	.002	.002	1	2
BLOOD_Leukemia	BDH1 →	+4.309	+4.560	.007	.007	1	2
BLOOD_Leukemia	DNAJC18 →	+4.157	+5.430	<.001	<.001	1	2
BLOOD_Leukemia	UPB1 →	+4.309	+4.560	.007	.007	1	1
BLOOD_Leukemia	GGT1 →	+4.309	+4.560	.007	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 691 associations by consensus.

DNAJC1 by MDK expression — BLOOD_Leukemia

Explore this box plot interactively →