MDH2

Across TCGA pan-cancer cohorts, MDH2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MDH2 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MDH2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MDH2 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, CCRCC, and LUAD are the cancer types where MDH2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	1.000	0.912	.013	30	view →
CCRCC	DFS	Tertile	All	0.648	0.960	.003	25	view →
LUAD	DFS	Tertile	II,III,IV	0.968	0.644	.006	19	view →
GBM	DFS	Quartile	All	0.838	0.680	.006	8	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.784	.015	6	view →
HNSC	DFS	Tertile	All	0.680	0.848	.029	3	view →
PDAC	OS	Quartile	All	0.593	0.408	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MDH2–COAD (DFS)

Open the COAD breakdown →