MDH2

Across TCGA patient cohorts, MDH2 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,255 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDH2-associated proteins across cancer lineages are PUS7, WDR36, and BAZ1B. Each is linked with MDH2 in more than 8 cancer types. Because this analysis shows association rather than direction, both MDH2-to-partner and partner-to-MDH2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDH2 versus PUS7 in LSCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH2→partner) and Y-score (partner→MDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PUS7 →	+0.593	+0.599	<.001	<.001	3	9
LSCC	WDR36 →	+0.313	+0.596	<.001	<.001	3	7
BRCA	BAZ1B →	+0.264	+0.213	<.001	.008	3	7
BRCA	GTF2I →	+0.470	+0.492	<.001	<.001	3	7
LSCC	NSUN5 →	+0.342	+0.642	<.001	<.001	3	7
OV	PEX1 →	+0.367	+0.573	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,255 associations by consensus.

MDH2 vs PUS7 — LSCC

Explore this scatter interactively →