MDH2

Across TCGA patient cohorts, MDH2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDH2-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and mTOR_pS2448. Each is linked with MDH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDH2-to-partner and partner-to-MDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MDH2-low versus MDH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH2→partner) and Y-score (partner→MDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.257	-3.169	.003	.019	3	1
UCEC	Ku80 →	+0.249	+2.183	.044	.035	3	1
UCEC	mTOR_pS2448 →	-0.208	-3.156	.007	.018	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.696	-2.999	.003	.035	3	1
UCEC	PDK1_pS241 →	+0.177	+2.183	.048	.035	3	1
UCEC	Rictor_pT1135 →	-0.122	-3.000	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK_pT183_Y185 by MDH2 expression — UCEC

Explore this box plot interactively →