MDH2

Across TCGA cell cohorts, MDH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,294 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MDH2-associated GO terms across cancer lineages are Ribosomal large subunit assembly, Mitochondrial ribosome assembly, and 2-oxoglutarate decarboxylation to succinyl-CoA. Each is linked with MDH2 in more than 13 cancer types. Because this analysis shows association rather than direction, both MDH2-to-partner and partner-to-MDH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal large subunit assembly grouped by MDH2-low versus MDH2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDH2→partner) and Y-score (partner→MDH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ribosomal large subunit assembly →	+0.145	+0.716	<.001	<.001	3	14
LARGE_INTESTINE	Mitochondrial ribosome assembly →	+0.085	+0.562	<.001	<.001	3	14
PANCREAS	2-oxoglutarate decarboxylation to succinyl-CoA →	+0.124	+0.760	.001	<.001	3	13
LUNG_SCLC	Malate-aspartate shuttle →	+0.126	+0.612	<.001	<.001	3	13
LARGE_INTESTINE	Mitochondrial large ribosomal subunit assembly →	+0.109	+0.510	<.001	<.001	2	13
BLOOD_Lymphoma	Pre-mRNA catabolic process →	+0.172	+1.397	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,294 associations by consensus.

Ribosomal large subunit assembly by MDH2 expression — BONE

Explore this box plot interactively →