MDGA2

Across TCGA patient cohorts, MDGA2 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDGA2-associated genes across cancer lineages are PKC-delta_pS664, MYH11, and XBP1. Each is linked with MDGA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MDGA2-to-partner and partner-to-MDGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by MDGA2-low versus MDGA2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDGA2→partner) and Y-score (partner→MDGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PKC-delta_pS664 →	-0.139	-3.000	.046	.036	3	3
SKCM	MYH11 →	-0.999	-3.169	.015	.018	3	3
LUAD	XBP1 →	-0.155	-1.807	.021	.026	3	3
LUAD	Bap1-c-4 →	+0.172	+2.195	.021	.033	3	3
UCEC	FoxM1 →	+0.136	+0.866	.045	.045	3	3
COAD	Caspase-7-cleavedD198 →	+1.282	+2.815	.003	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

PKC-delta_pS664 by MDGA2 expression — STAD

Explore this box plot interactively →