MDGA2

Across TCGA cell cohorts, MDGA2 mutation is significantly associated with the RNA expression of many other genes, with 226 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDGA2-associated genes across cancer lineages are KCNA6, GP9, and FAM170A. Each is linked with MDGA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MDGA2-to-partner and partner-to-MDGA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNA6 grouped by MDGA2-low versus MDGA2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDGA2→partner) and Y-score (partner→MDGA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KCNA6 →	+1.026	+3.426	.005	.007	3	3
BLOOD_Lymphoma	GP9 →	+0.179	+3.452	<.001	.004	3	2
LUNG_NSCLC_LUSC	FAM170A →	+0.091	+3.762	<.001	.001	3	2
LUNG_SCLC	C12orf40 →	+0.017	+4.321	.003	<.001	3	2
URINARY_TRACT	TPPP2 →	+0.063	+4.050	<.001	.002	3	2
URINARY_TRACT	SLC13A2 →	+0.024	+3.584	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 226 associations by consensus.

KCNA6 by MDGA2 expression — BLOOD_Leukemia

Explore this box plot interactively →