MDGA1

Across TCGA cell cohorts, MDGA1 mutation is significantly associated with the RNA expression of many other genes, with 691 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDGA1-associated genes across cancer lineages are GPR101, OR4F15, and PRAMEF7. Each is linked with MDGA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDGA1-to-partner and partner-to-MDGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by MDGA1-low versus MDGA1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDGA1→partner) and Y-score (partner→MDGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GPR101 →	+0.106	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR4F15 →	+0.043	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF7 →	+0.116	+4.736	<.001	.009	3	2
UPPER_AERODIGESTIVE_TRACT	OR2B3 →	+0.061	+4.736	<.001	.009	3	2
BLOOD_Leukemia	LRIT1 →	+0.026	+3.269	<.001	.007	3	2
SOFT_TISSUE	ETDB →	+0.076	+4.222	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 691 associations by consensus.

GPR101 by MDGA1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →