MDGA1

Across TCGA cell cohorts, MDGA1 mutation is significantly associated with the mutation status of many other genes, with 4,927 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDGA1-associated genes across cancer lineages are CHD7, SHC1, and DOCK7. Each is linked with MDGA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MDGA1-to-partner and partner-to-MDGA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD7 grouped by MDGA1-low versus MDGA1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDGA1→partner) and Y-score (partner→MDGA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CHD7 →	+3.722	+4.022	.003	.003	1	6
UPPER_AERODIGESTIVE_TRACT	SHC1 →	+4.392	+4.954	.008	.008	1	5
LARGE_INTESTINE	DOCK7 →	+2.597	+2.728	<.001	<.001	1	5
LARGE_INTESTINE	EPRS1 →	+3.030	+3.220	<.001	<.001	1	5
LARGE_INTESTINE	HECTD4 →	+1.416	+2.473	.002	.002	1	5
SOFT_TISSUE	WDFY4 →	+2.985	+3.562	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,927 associations by consensus.

CHD7 by MDGA1 expression — LUNG_SCLC

Explore this box plot interactively →