MDFIC2

Across TCGA pan-cancer cohorts, MDFIC2 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated MDFIC2 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher MDFIC2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MDFIC2 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

LIHC, BRCA, and UCEC are the cancer types where MDFIC2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Tertile	II,III,IV	0.153	0.449	<.001	81	view →
BRCA	DFS	Tertile	All	0.865	0.950	.001	48	view →
UCEC	DFS	Tertile	All	0.791	0.902	.003	36	view →
THCA	OS	Tertile	III,IV	0.908	0.976	.013	33	view →
OV	OS	Tertile	IV	0.301	0.637	.047	24	view →
BLCA	DFS	Tertile	All	1.000	0.290	.035	18	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →
SARC	DFS	Tertile	All	0.421	0.625	.003	18	view →
CESC	DFS	Tertile	II,III,IV	0.188	0.710	.005	18	view →
HNSC	DFS	Tertile	II,III,IV	0.265	0.665	.029	18	view →
GBM	OS	Tertile	All	0.115	0.422	.001	12	view →
MESO	DFS	Quartile	IV	0.132	0.392	.013	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

MDFIC2–LIHC (DFS)

Open the LIHC breakdown →