MDFIC

Across TCGA patient cohorts, MDFIC protein abundance is significantly associated with the RNA expression of many other genes, with 2,423 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MDFIC-associated genes across cancer lineages are SEMA3G, TTF2, and VEGFC. Each is linked with MDFIC in more than 1 cancer types. Because this analysis shows association rather than direction, both MDFIC-to-partner and partner-to-MDFIC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDFIC versus SEMA3G in CCRCC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDFIC→partner) and Y-score (partner→MDFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SEMA3G →	+1.687	+0.547	.004	.004	3	2
CCRCC	TTF2 →	-0.798	-0.789	.004	.007	3	2
LSCC	VEGFC →	+1.281	+0.448	.004	.007	3	2
CCRCC	SPRY1 →	+1.238	+0.571	.003	.001	3	2
CCRCC	NOS3 →	+0.726	+0.539	.006	.002	3	2
CCRCC	RNU6-519P →	-0.950	-0.588	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,423 associations by consensus.

MDFIC vs SEMA3G — CCRCC

Explore this scatter interactively →