MDFIC

Across TCGA patient cohorts, MDFIC mutation is significantly associated with the RNA expression of many other genes, with 1,603 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDFIC-associated genes across cancer lineages are RNU4-61P, RNA5SP64, and RNA5SP158. Each is linked with MDFIC in more than 1 cancer types. Because this analysis shows association rather than direction, both MDFIC-to-partner and partner-to-MDFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-61P grouped by MDFIC-low versus MDFIC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDFIC→partner) and Y-score (partner→MDFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-61P →	+0.255	+3.766	<.001	.005	3	2
ESCA	RNA5SP64 →	+0.311	+5.450	<.001	.004	3	2
UCEC	RNA5SP158 →	+0.148	+3.464	<.001	.002	3	2
UCEC	RNU6-358P →	+0.286	+2.455	.001	.003	3	2
UCEC	TRDV3 →	+0.381	+1.877	<.001	.002	3	2
UCEC	PRELID2P1 →	+0.215	+2.184	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,603 associations by consensus.

RNU4-61P by MDFIC expression — SKCM

Explore this box plot interactively →