MDFIC

Across TCGA patient cohorts, MDFIC mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDFIC-associated genes across cancer lineages are 4E-BP1, MEK1, and Notch1. Each is linked with MDFIC in more than 1 cancer types. Because this analysis shows association rather than direction, both MDFIC-to-partner and partner-to-MDFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MDFIC-low versus MDFIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDFIC→partner) and Y-score (partner→MDFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.364	+2.029	<.001	.017	3	2
UCEC	MEK1 →	+0.343	+2.700	.019	.006	3	1
UCEC	Notch1 →	+0.157	+2.232	.005	.005	3	1
UCEC	p62 Lck ligand →	+0.350	+2.415	.007	.003	3	1
UCEC	PDCD4 →	-0.567	-3.690	.002	.001	3	1
UCEC	Annexin-1 →	+0.623	+2.604	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

4E-BP1 by MDFIC expression — UCEC

Explore this box plot interactively →