MDFIC

Across TCGA cell cohorts, MDFIC RNA expression is significantly associated with the go_rna of many other GO terms, with 4,424 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MDFIC-associated GO terms across cancer lineages are Endosomal transport, Positive regulation of focal adhesion assembly, and Regulation of stress-activated protein kinase signaling cascade. Each is linked with MDFIC in more than 10 cancer types. Because this analysis shows association rather than direction, both MDFIC-to-partner and partner-to-MDFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endosomal transport grouped by MDFIC-low versus MDFIC-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDFIC→partner) and Y-score (partner→MDFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Endosomal transport →	+0.050	+1.041	.002	.002	3	11
LIVER	Positive regulation of focal adhesion assembly →	+0.136	+2.456	.001	.001	3	10
LUNG_NSCLC_LUAD	Regulation of stress-activated protein kinase signaling cascade →	+0.065	+1.151	.005	.001	3	10
LUNG_NSCLC_LUSC	Regulation of angiotensin-activated signaling pathway →	+0.173	+2.095	.004	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.060	+0.825	.004	.008	3	9
LIVER	Regulation of transforming growth factor beta receptor signaling pathway →	+0.054	+2.118	.003	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,424 associations by consensus.

Endosomal transport by MDFIC expression — SKIN

Explore this box plot interactively →