MDFIC

Across TCGA cell cohorts, MDFIC mutation is significantly associated with the drug of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MDFIC-associated genes across cancer lineages are OF-1, TL-2-105, and CX-5461. Each is linked with MDFIC in more than 1 cancer types. Because this analysis shows association rather than direction, both MDFIC-to-partner and partner-to-MDFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OF-1 grouped by MDFIC-low versus MDFIC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDFIC→partner) and Y-score (partner→MDFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OF-1 →	+0.329	+2.646	.022	.047	3	1
LARGE_INTESTINE	TL-2-105 →	+0.423	+2.652	.032	.045	3	1
LARGE_INTESTINE	CX-5461 →	+0.646	+2.652	.028	.045	3	1
LARGE_INTESTINE	LGK974 →	+0.351	+2.646	.033	.047	1	1
LARGE_INTESTINE	GSK2606414 →	+0.485	+2.769	.011	.040	1	1
LARGE_INTESTINE	TAF1_5496 →	+0.687	+2.777	.001	.038	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OF-1 by MDFIC expression — LARGE_INTESTINE

Explore this box plot interactively →