MDC1

Across TCGA pan-cancer cohorts, MDC1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MDC1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MDC1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MDC1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where MDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	31	view →
LSCC	OS	Median	All	0.899	0.696	.008	11	view →
PDAC	DFS	Median	All	0.708	0.816	.017	7	view →
GBM	OS	Tertile	All	0.605	0.362	.039	3	view →
LUAD	DFS	Quartile	All	0.576	1.000	.049	2	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MDC1–HNSC (OS)

Open the HNSC breakdown →