MDC1

Across TCGA patient cohorts, MDC1 protein abundance is significantly associated with the protein abundance of many other proteins, with 42,128 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MDC1-associated proteins across cancer lineages are BAZ1B, DAXX, and DEK. Each is linked with MDC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both MDC1-to-partner and partner-to-MDC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MDC1 versus BAZ1B in BRCA, with a Pearson correlation of 0.54.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MDC1→partner) and Y-score (partner→MDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BAZ1B →	+0.415	+0.378	<.001	<.001	3	10
GBM	DAXX →	+0.327	+0.289	<.001	<.001	3	10
LSCC	DEK →	+0.417	+0.461	<.001	<.001	3	10
GBM	SMARCC1 →	+0.467	+0.362	<.001	<.001	3	10
OV	MDC1_S882 →	+1.660	+0.461	<.001	<.001	3	10
LSCC	NUP153 →	+0.379	+0.452	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 42,128 associations by consensus.

MDC1 vs BAZ1B — BRCA

Explore this scatter interactively →