MDC1

Across TCGA patient cohorts, MDC1 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MDC1-associated genes across cancer lineages are 4E-BP1, INPP4B, and PCNA. Each is linked with MDC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MDC1-to-partner and partner-to-MDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MDC1-low versus MDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDC1→partner) and Y-score (partner→MDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.348	+4.392	<.001	<.001	3	4
UCEC	INPP4B →	-0.189	-1.440	.047	.020	3	3
STAD	PCNA →	+0.235	+3.459	.045	.004	3	3
STAD	C-Raf →	+0.143	+3.169	.027	.018	3	3
COAD	eIF4E →	+0.216	+2.832	.027	.035	2	4
COAD	ASNS →	+0.489	+2.815	.024	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

4E-BP1 by MDC1 expression — UCEC

Explore this box plot interactively →