MDC1

Across TCGA cell cohorts, MDC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDC1-associated GO terms across cancer lineages are Chromosome condensation, Mitotic sister chromatid segregation, and Sister chromatid segregation. Each is linked with MDC1 in more than 17 cancer types. Because this analysis shows association rather than direction, both MDC1-to-partner and partner-to-MDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome condensation grouped by MDC1-low versus MDC1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MDC1→partner) and Y-score (partner→MDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Chromosome condensation →	+0.209	+1.482	.002	<.001	3	18
BONE	Mitotic sister chromatid segregation →	+0.125	+1.184	.002	<.001	3	17
BONE	Sister chromatid segregation →	+0.123	+1.184	.001	<.001	3	17
BONE	Negative regulation of RNA export from nucleus →	+0.147	+1.296	<.001	<.001	3	17
SOFT_TISSUE	Protein localization to chromatin →	+0.118	+1.191	<.001	<.001	3	16
BONE	Mitotic nuclear division →	+0.103	+1.097	.004	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,198 associations by consensus.

Chromosome condensation by MDC1 expression — BONE

Explore this box plot interactively →