MDC1

Across TCGA cell cohorts, MDC1 mutation is significantly associated with the RNA expression of many other genes, with 380 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MDC1-associated genes across cancer lineages are KRTAP6-1, OR5H2, and KRTAP10-1. Each is linked with MDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MDC1-to-partner and partner-to-MDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by MDC1-low versus MDC1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MDC1→partner) and Y-score (partner→MDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP6-1 →	+0.052	+4.643	<.001	.004	3	2
LUNG_SCLC	OR5H2 →	+0.037	+4.643	<.001	.004	3	2
UPPER_AERODIGESTIVE_TRACT	KRTAP10-1 →	+0.072	+4.357	<.001	.006	3	2
BREAST	OR13D1 →	+0.031	+3.232	<.001	.006	3	2
BREAST	CYP3A43 →	+0.071	+3.662	.004	.009	3	2
LARGE_INTESTINE	HINT3 →	+0.639	+3.364	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 380 associations by consensus.

KRTAP6-1 by MDC1 expression — LUNG_SCLC

Explore this box plot interactively →