MCTS1

Across TCGA patient cohorts, MCTS1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCTS1-associated genes across cancer lineages are eEF2, FOXO3a_pS318_S321, and JNK_pT183_Y185. Each is linked with MCTS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCTS1-to-partner and partner-to-MCTS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MCTS1-low versus MCTS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCTS1→partner) and Y-score (partner→MCTS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.377	+2.115	.015	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.146	-2.575	.007	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-2.102	.004	.019	3	1
UCEC	JNK2 →	+0.221	+2.115	.010	.019	3	1
UCEC	MEK1 →	+0.490	+3.459	.002	.005	3	1
UCEC	mTOR_pS2448 →	-0.213	-2.807	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by MCTS1 expression — UCEC

Explore this box plot interactively →