MCTP2

Across TCGA cell cohorts, MCTP2 mutation is significantly associated with the RNA expression of many other genes, with 920 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCTP2-associated genes across cancer lineages are LRRC3C, TTPA, and IARS1. Each is linked with MCTP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCTP2-to-partner and partner-to-MCTP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by MCTP2-low versus MCTP2-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCTP2→partner) and Y-score (partner→MCTP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	LRRC3C →	+0.031	+3.502	.001	.007	3	2
BLOOD_Leukemia	TTPA →	+0.610	+3.824	.008	.001	3	2
LARGE_INTESTINE	IARS1 →	+0.746	+3.212	.001	.006	3	2
LIVER	LCT →	+0.029	+3.754	.009	.009	3	1
LIVER	GHSR →	+0.033	+3.502	.001	.007	3	1
LIVER	GPR42 →	+0.006	+3.459	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 920 associations by consensus.

LRRC3C by MCTP2 expression — LIVER

Explore this box plot interactively →