MCTP2

Across TCGA cell cohorts, MCTP2 mutation is significantly associated with the mutation status of many other genes, with 5,021 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCTP2-associated genes across cancer lineages are TRIM2, FCGBP, and DSCAML1. Each is linked with MCTP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MCTP2-to-partner and partner-to-MCTP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM2 grouped by MCTP2-low versus MCTP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCTP2→partner) and Y-score (partner→MCTP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIM2 →	+5.339	+4.772	.004	.004	1	5
KIDNEY	FCGBP →	+5.000	+5.000	.006	.006	1	4
OVARY	DSCAML1 →	+4.047	+5.099	<.001	<.001	1	4
LARGE_INTESTINE	ZNF516 →	+2.321	+3.169	<.001	<.001	1	4
LARGE_INTESTINE	RASAL3 →	+2.643	+2.321	.004	.004	1	4
CNS	VWF →	+2.706	+3.389	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,021 associations by consensus.

TRIM2 by MCTP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →