MCTP1

Across TCGA cell cohorts, MCTP1 mutation is significantly associated with the RNA expression of many other genes, with 861 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCTP1-associated genes across cancer lineages are KRTAP7-1, HELT, and ZNF705G. Each is linked with MCTP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCTP1-to-partner and partner-to-MCTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP7-1 grouped by MCTP1-low versus MCTP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCTP1→partner) and Y-score (partner→MCTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP7-1 →	+0.095	+5.539	<.001	.003	3	2
CNS	HELT →	+0.027	+4.321	<.001	.009	3	1
CNS	ZNF705G →	+0.011	+4.315	<.001	.006	3	1
CNS	OOSP4A →	+0.055	+4.321	<.001	.009	3	1
BLOOD_Leukemia	PRAMEF1 →	+0.016	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	OR10V1 →	+0.046	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 861 associations by consensus.

KRTAP7-1 by MCTP1 expression — BLOOD_Leukemia

Explore this box plot interactively →