MCTP1

Across TCGA cell cohorts, MCTP1 mutation is significantly associated with the mutation status of many other genes, with 4,599 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCTP1-associated genes across cancer lineages are SCAF8, KIF7, and R3HDM2. Each is linked with MCTP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCTP1-to-partner and partner-to-MCTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCAF8 grouped by MCTP1-low versus MCTP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCTP1→partner) and Y-score (partner→MCTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCAF8 →	+5.014	+5.584	.003	.003	1	4
SKIN	KIF7 →	+3.718	+3.053	.006	.006	1	4
BLOOD_Lymphoma	R3HDM2 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	KCNQ3 →	+4.014	+4.969	.008	.008	1	4
CNS	KCNH4 →	+4.614	+4.614	.006	.006	1	4
BLOOD_Lymphoma	RBM26 →	+4.429	+5.247	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,599 associations by consensus.

SCAF8 by MCTP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →