Across TCGA patient cohorts, MCRS1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCRS1-associated genes across cancer lineages are Annexin_VII, Cyclin-B1, and mTOR_pS2448. Each is linked with MCRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCRS1-to-partner and partner-to-MCRS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCRS1→partner) and Y-score (partner→MCRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin_VII →	-0.118	-1.700	.045	.044	3	2
UCEC	Cyclin-B1 →	+0.580	+3.169	.014	.018	3	2
UCEC	mTOR_pS2448 →	-0.153	-2.986	.015	.035	3	1
UCEC	Notch1 →	+0.247	+2.469	<.001	.010	2	2
UCEC	PCNA →	+0.284	+3.321	.001	.009	3	1
UCEC	PDCD4 →	-0.489	-1.700	.014	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

MCRS1 survival (RNA) · tumor vs normal (RNA) · all MCRS1 data types