Across TCGA cell cohorts, MCRS1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MCRS1-associated genes across cancer lineages are OR11H2, CRYGD, and SHCBP1L. Each is linked with MCRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCRS1-to-partner and partner-to-MCRS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCRS1→partner) and Y-score (partner→MCRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1
SKIN	CRYGD →	+0.418	+4.415	<.001	.007	3	1
SKIN	SHCBP1L →	+0.058	+4.930	<.001	.001	3	1
SKIN	TMEM82 →	+0.034	+4.273	<.001	.006	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

MCRS1 survival (RNA) · tumor vs normal (RNA) · all MCRS1 data types