Across TCGA cell cohorts, MCRS1 mutation is significantly associated with the mutation status of many other genes, with 1,227 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible MCRS1-associated genes across cancer lineages are EPHA2, DIP2C, and ACTG2. Each is linked with MCRS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCRS1-to-partner and partner-to-MCRS1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCRS1→partner) and Y-score (partner→MCRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	EPHA2 →	+4.392	+4.392	.009	.009	1	4
STOMACH	DIP2C →	+3.357	+4.285	.005	.005	1	4
UPPER_AERODIGESTIVE_TRACT	ACTG2 →	+4.954	+4.392	.008	.008	1	4
STOMACH	DAXX →	+3.357	+4.285	.005	.005	1	3
SKIN	CASK →	+4.392	+4.392	.009	.009	1	3
SKIN	ING1 →	+4.392	+4.392	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,227 associations by consensus.

Exploration

MCRS1 survival (RNA) · tumor vs normal (RNA) · all MCRS1 data types